A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia.

@article{Windrem2014ACA,
  title={A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia.},
  author={Martha S. Windrem and Steven J. Schanz and Carolyn Alexandria Morrow and Jared Munir and Devin Chandler-Militello and Su Xing Wang and Steven A Goldman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 48},
  pages={16153-61}
}
Neonatally transplanted human glial progenitor cells (hGPCs) densely engraft and myelinate the hypomyelinated shiverer mouse. We found that, in hGPC-xenografted mice, the human donor cells continue to expand throughout the forebrain, systematically replacing the host murine glia. The differentiation of the donor cells is influenced by the host environment, such that more donor cells differentiated as oligodendrocytes in the hypomyelinated shiverer brain than in myelin wild-types, in which hGPCs… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 76 times over the past 90 days. VIEW TWEETS
Blog posts, news articles and tweet counts and IDs sourced by
Altmetric.com