A compendium of human mitochondrial gene expression machinery with links to disease.

@article{Shutt2010ACO,
  title={A compendium of human mitochondrial gene expression machinery with links to disease.},
  author={Timothy E. Shutt and Gerald S Shadel},
  journal={Environmental and molecular mutagenesis},
  year={2010},
  volume={51 5},
  pages={360-79}
}
Mammalian mitochondrial DNA encodes 37 essential genes required for ATP production via oxidative phosphorylation, instability or misregulation of which is associated with human diseases and aging. Other than the mtDNA-encoded RNA species (13 mRNAs, 12S and 16S rRNAs, and 22 tRNAs), the remaining factors needed for mitochondrial gene expression (i.e., transcription, RNA processing/modification, and translation), including a dedicated set of mitochondrial ribosomal proteins, are products of… CONTINUE READING

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