A compass that points to lupus: genetic studies on type I interferon pathway

@article{Kyogoku2007ACT,
  title={A compass that points to lupus: genetic studies on type I interferon pathway},
  author={Chieko Kyogoku and Naoyuki Tsuchiya},
  journal={Genes and Immunity},
  year={2007},
  volume={8},
  pages={445-455}
}
It was more than 20 years ago that patients with systemic lupus erythematosus (SLE) were first reported to display elevated serum levels of type I interferon (IFN). Since then, extensive studies revealed a crucial role for type I IFN in SLE pathogenesis. The current model proposes that small increase of type I IFN production by plasmacytoid dendritic cells (pDCs) is sufficient to induce unabated activation of immature peripheral DCs. IFN-matured DCs select and activate autoreactive T cells and… CONTINUE READING
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Replication of the genetic effects of IFN regulatory factor 5 ( IRF 5 ) on systemic lupus erythematosus in a Korean population

  • HM Cann, C deToma, L Cazes, MF Legrand, V Morel, L Piouffre
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