A comparison study of lipid and androgen metabolism with triphasic oral contraceptive formulations containing norgestimate or levonorgestrel

@article{Janaud1992ACS,
  title={A comparison study of lipid and androgen metabolism with triphasic oral contraceptive formulations containing norgestimate or levonorgestrel},
  author={A. Janaud and J. Rouffy and D. Upmalis and M. Dain},
  journal={Acta Obstetricia et Gynecologica Scandinavica},
  year={1992},
  volume={71}
}
The effects of norgestimate triphasic (Ortho Tri‐Cyclen®, Tri‐Cilest®) and levonorgestrel triphasic (Triphasil®) formulations on lipid and androgen metabolism were assessed in a study of 66 healthy women treated through six menstrual cycles. Levels of the following were measured: cholesterol and its subfractions, triglycerides. carrier lipoproteins, estradiol, testosterone, and sex hormone binding globulin (SHBG). Comparison of baseline values with values after 3 and 6 months of treatment… Expand
The role of triphasic levonorgestrel in oral contraception: a review of metabolic and hemostatic effects.
  • U. Lachnit-Fixson
  • Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 1996
TLDR
The effect of triphasic levonorgestrel appears to be balanced, with most studies reporting a corresponding increase in anti-coagulant-fibrinolytic activity, which is probably not clinically relevant in terms of an altered risk of cardiovascular disease. Expand
Efficacy and safety of a monophasic and a triphasic oral contraceptive containing norgestimate
TLDR
Both monophasic and triphasic formulations of ethinyl estradiol plus norgestimate offer contraceptive efficacy equivalent to that of other oral contraceptives and consistently showed favorable impact on metabolic parameters, including elevations in serum high-density lipoprotein cholesterol, and reductions in the low-densitylipoprotein/high-density cholesterol ratio, the parameter considered most sensitive for atherosclerotic risk. Expand
Effects of oral contraceptives on metabolic parameters in adult premenopausal women: a meta-analysis
TLDR
Most progestins increase both TG and HDLc, their effect on LDLc varies widely, and the antiandrogen progestin dienogest and cyproterone displayed the most favorable metabolic profile, while levonorgestrel displayed the least favorable. Expand
The paradigm of norgestimate: a third-generation testosterone-derivative progestin with a peripheral anti-androgenic activity and the lowest risk of venous thromboembolism
TLDR
A narrative review of the available data on the pharmacotherapy of NGM in combined hormonal contraceptives (CHCs) in terms of contraceptive efficacy, venous thromboembolism risk, safety, tolerability and bleeding patterns is reviewed. Expand
Comparative Review of Recently Introduced Oral Contraceptives Containing Norgestimate, Desogestrel, and Gestodene and Older Oral Contraceptives
TLDR
In the search for compounds that offer women both efficacy and contraceptive benefits with the lowest incidence of adverse effects, the introduction of the norgestimate and desogestrel-containing OCs represents an important milestone. Expand
Double-blind, randomized study comparing the effects of two monophasic oral contraceptives containing ethinylestradiol (20 μg or 30 μg) and levonorgestrel (100 μg or 150 μg) on lipoprotein metabolism
TLDR
The effects of the two combinations of ethinylestradiol and levonorgestrel on triglyceride-rich lipoproteins appear less pronounced than those produced by preparations containing third-generation progestins. Expand
Minimal androgenic activity of a new oral contraceptive containing norethindrone acetate and graduated doses of ethinyl estradiol.
TLDR
The observed changes in circulating SHBG and free testosterone concentrations indicate that Estrostep has little, if any, intrinsic androgenic activity. Expand
The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis
TLDR
COCs decrease circulating levels of total T and free T and increase SBHG concentrations, and suppressive effects on T levels were not different when comparing different types of progestins. Expand
Triphasic oral contraceptives: review and comparison of various regimens.
TLDR
Both triphasics and monophasics have minimal effects on carbohydrate and lipid metabolism and hemostasis parameters, and therefore comparable low risks of coronary heart disease. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
Supportive European Data on a New Oral Contraceptive Containing Norgestimate
  • H. Becker
  • Medicine
  • Acta obstetricia et gynecologica Scandinavica. Supplement
  • 1990
TLDR
The drug had no effect on estrogen‐mediated fibrin formation nor on the activity of coagulation inhibiting or promoting factors, and lipid metabolism was positively influenced by the drug. Expand
SEX HORMONE BINDING GLOBULIN CAPACITY AS AN INDEX OF OESTROGENICITY OR ANDROGENICITY IN WOMEN ON ORAL CONTRACEPTIVE STEROIDS
TLDR
Women with a high pre‐treatment SHBG level might be more suited to combination OC with d‐norgestrel or the 19‐norprogestagen‘mini’pills, while combined OC preparations causing some elevation of SHBG might be preferable. Expand
[Clinical evidence of the minimal androgenic activity of norgestimate].
TLDR
Norgestimate (NGM) is a new progestogen presenting an exceptional profile of biological activity, and has proved to be extremely selective, as observed during the clinical trials, in order to confirm clinically the low androgenic activity of NGM. Expand
Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity.
TLDR
Norgestimate and its 17-deacetylated metabolite demonstrate very poor affinity for androgen receptors compared with levonorgestrel and gestodene and do not exhibit androgenic activity when measured as the stimulation of prostatic growth in immature rats. Expand
The effect of progestins in combined oral contraceptives on serum lipids with special reference to high-density lipoproteins.
TLDR
The levonorgestrel-containing pills and the progestin-only OC significantly depressed HDL2 cholesterol levels and the ratio of HDL2 to LDL cholesterol. Expand
Oral contraceptives, lipids and cardiovascular disease.
TLDR
Assessment of the effect of different oral contraceptive formulations on serum lipid levels finds that the preferred formulations should contain a low dose of ethynyloestradiol and should not increase serum levels of cholesterol and LDL-C or reduce those of HDL-C. Expand
Free estradiol, free testosterone, and sex hormone-binding globulin in perimenopausal women.
TLDR
In normal women, the menopause is not associated with changes in SHBG or % free steroids, and the measurement of E2 could be used to predict the mass of free E2 in these women, and there were strong correlations between the E2 andfree E2 concentrations. Expand
Immunochemical characterization and quantitation of human sex steroid binding plasma protein
TLDR
The purpose of the present work was to purify the protein, to prepare a rabbit monospecific antiserum and to develop an immunoelectrophoretic assay of h-SBP, which is specific, accurate and sensitive. Expand
PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE
TLDR
The body cholesterol pool increases with decreasing plasma-high-density-lipoprotein (H.D.L.) but is unrelated to the plasma concentrations of total cholesterol and other lipoproteins, and it is proposed that a reduction of plasma-H.H.L.D., is reduced in several conditions associated with an increased risk of future ischaemic heart-disease, by impairing the clearance of cholesterol from the arterial wall. Expand
Efficacy and Clinical Profile of a New Oral Contraceptive Containing Norgestimate: U.S. Clinical Trials
  • S. Corson
  • Medicine
  • Acta obstetricia et gynecologica Scandinavica. Supplement
  • 1990
The search for a highly selective progestin that exerts a potent and targeted progestational response with minimal or absent androgenic effect has paralleled investigation into the possible impact ofExpand
...
1
2
...