A comparison study of amitriptyline and nortriptyline with plasma levels.

@article{Ziegler1977ACS,
  title={A comparison study of amitriptyline and nortriptyline with plasma levels.},
  author={Veronika Ziegler and Paula J. Clayton and Jeffery Biggs},
  journal={Archives of general psychiatry},
  year={1977},
  volume={34 5},
  pages={607-12}
}
Forty-one depressed outpatients were treated for six weeks after random assignment to amitriptyline hydrochloride (N = 22) or nortriptyline hydrochloride (N = 19). On a mean daily dose of 119 mg, amitriptyline-treated patients had a mean tricyclic level (amitriptyline plus nortriptyline) of 120 ng/ml. Nortriptyline-treated patients on a mean dose of 117 mg/day had a mean nortriptyline level of 141 ng/ml. The two drugs were equally effective in the treatment of depression. The correlation… CONTINUE READING

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