A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation.

@article{Wenzel2004ACO,
  title={A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation.},
  author={Volker Wenzel and Anette C. Krismer and Hans Richard Arntz and Helmut Sitter and Karl H. Stadlbauer and Karl H. Lindner},
  journal={The New England journal of medicine},
  year={2004},
  volume={350 2},
  pages={
          105-13
        }
}
BACKGROUND Vasopressin is an alternative to epinephrine for vasopressor therapy during cardiopulmonary resuscitation, but clinical experience with this treatment has been limited. METHODS We randomly assigned adults who had had an out-of-hospital cardiac arrest to receive two injections of either 40 IU of vasopressin or 1 mg of epinephrine, followed by additional treatment with epinephrine if needed. The primary end point was survival to hospital admission, and the secondary end point was… Expand

Paper Mentions

Interventional Clinical Trial
A randomized controlled trial did not show benefit of vasopressin versus epinephrine in inhospital cardiac arrest. Preceding laboratory data suggest that combined vasopressin and… Expand
ConditionsHeart Arrest
InterventionDrug
Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest.
TLDR
Vasopressin administered with epinephrine does not increase the rate of return of spontaneous circulation and survival duration for subjects admitted to the hospital did not differ between groups. Expand
Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation.
TLDR
The combination of vasopressin and epinephrine during advanced cardiac life support for out-of-hospital cardiac arrest does not improve outcome and is not recommended. Expand
Reduced effectiveness of vasopressin in repeated doses for patients undergoing prolonged cardiopulmonary resuscitation.
TLDR
This is the first report of a possible vasopressin-alone resuscitation without additional epinephrine for cardiopulmonary arrest patients receiving prolonged CPR, and repeated injections of either vasopressingin or epinechery during prolonged advanced cardiac life support resulted in comparable survival. Expand
Vasopressin administered with epinephrine is associated with a return of a pulse in out-of-hospital cardiac arrest.
TLDR
There is an association between using vasopressin in combination with epinephrine and restoration of circulation after out-of-hospital cardiac arrest. Expand
Vasopressin improves outcome in out-of-hospital cardiopulmonary resuscitation of ventricular fibrillation and pulseless ventricular tachycardia: a observational cohort study
TLDR
The greater 24-hour survival rate in vasopressin-treated patients suggests that consideration of combined vasopressingin and adrenaline is warranted for the treatment of refractory ventricular fibrillation or pulseless ventricular tachycardia. Expand
Vasopressin and epinephrine versus epinephrine in management of patients with cardiac arrest: a meta-analysis
TLDR
A systematic review of the efficacy of vasopressin and epinephrine use found that its combined use is better for 24h survival rate but only in one study which included 122 patients, and further investigation will be needed to support the use of this combination for cardiac arrest management. Expand
Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital cardiac arrest: a randomized clinical trial.
TLDR
Combined vasopressin-epinephrine and methylprednisolone during CPR and stress-dose hydrocortisone in postresuscitation shock, compared with epinephrine/saline placebo resulted in improved survival to hospital discharge with favorable neurological status. Expand
Vasopressin during cardiopulmonary resuscitation: A progress report
TLDR
In patients undergoing cardiopulmonary resuscitation, circulating endogenous vasopressin concentrations were significantly higher in successfully resuscitated patients than in patients who died, and vasoppressin was superior to epinephrine in patients with asystole, but the clinical study did not confirm laboratory data showing vasopressingin to be more effective than epinphrine in ventricular fibrillation and pulseless electrical activity. Expand
Compare the Effects of Epinephrine and Vasopressin in Return of Spontaneous Circulation
TLDR
Among patients with in-hospital cardiopulmonary arrest in this study no statistically significant difference was obtained between the results of treatment withEpinephrine alone and combination of epinephrine and vasopressin. Expand
Vasopressin, epinephrine, and corticosteroids for in-hospital cardiac arrest.
TLDR
In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest. Expand
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