A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing.

@article{Roguska1996ACO,
  title={A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing.},
  author={M A Roguska and Jan T. Pedersen and Andrew H. Henry and Stephen M. J. Searle and C M Roja and Birthe Avery and Mary Hoffee and STEPHEND. COOK and J. G. Lambert and Walter A. Bl{\"a}ttler and Anthony R. Rees and Braydon C. Guild},
  journal={Protein engineering},
  year={1996},
  volume={9 10},
  pages={895-904}
}
The variable domain resurfacing and CDR-grafting approaches to antibody humanization were compared directly on the two murine monoclonal antibodies N901 (anti-CD56) and anti-B4 (anti-CD19). Resurfacing replaces the set of surface residues of a rodent variable region with a human set of surface residues. The method of CDR-grafting conceptually consists of… CONTINUE READING

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