A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants

@article{Joffe1990ACO,
  title={A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants},
  author={Russell T. Joffe and William Singer},
  journal={Psychiatry Research},
  year={1990},
  volume={32},
  pages={241-251}
}
Several studies suggest that small amounts of triiodothyronine (T3) will convert tricyclic antidepressant nonresponders into responders within a few days to a few weeks. As thyroxine (T4) is converted to T3 to have its physiological effect, it has been assumed that T4 would have a similar antidepressant effect to that of T3. We carried out a randomized, double-blind evaluation of the antidepressant-potentiating effect of T3 as compared with T4. Significantly more patients responded to 3 weeks… CONTINUE READING

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