A comparison of trazodone and fluoxetine: implications for a serotonergic mechanis of antidepressant action

@article{Marek1992ACO,
  title={A comparison of trazodone and fluoxetine: implications for a serotonergic mechanis of antidepressant action},
  author={Gerard J. Marek and Christopher J. McDougle and Lawrence H. Price and Lewis S. Seiden},
  journal={Psychopharmacology},
  year={1992},
  volume={109},
  pages={2-11}
}
Trazodone is an atypical antidepressant drug that is commonly referred to as a serotonin (5-hydroxytryptamine; 5-HT) uptake inhibitor. However, the most potent pharmacological effect of trazodone appears to be antagonist action at 5-HT2/1C receptors. This is in contrast to fluoxetine, for which inhibition of 5-HT uptake is the most potent pharmacological action. The effects of trazodone and fluoxetine on several antidepressant drug screens are mediated by antagonist action at 5-HT2 receptors… CONTINUE READING