A comparison of the pharmacological properties of recombinant human and rat alpha(1)beta(2)gamma(2L) GABA(A) receptors in Xenopus oocytes.

@article{Rahman2008ACO,
  title={A comparison of the pharmacological properties of recombinant human and rat alpha(1)beta(2)gamma(2L) GABA(A) receptors in Xenopus oocytes.},
  author={Mozibur Rahman and Vijaya Bhaskar Borra and Monica Isaksson and Isak Nilsson Johansson and Gianna Ragagnin and Torbj{\"o}rn Carl B{\"a}ckstr{\"o}m and Marilyn D. Wang},
  journal={Clinical and experimental pharmacology & physiology},
  year={2008},
  volume={35 9},
  pages={
          1002-11
        }
}
In the present study, we compared the pharmacology, particularly neurosteroid modulation of the GABA(A) receptor, between human and rat alpha(1)beta(2)gamma(2)(L) GABA(A) receptors and between human receptors containing the long (L) and short (S) forms of the gamma(2)-subunit. We observed that maximum responses to GABA were significantly higher with the human alpha(1)beta(2)gamma(2)(L) receptor compared with the rat receptor. In terms of neurosteroid modulation, increases in the EC(15) response… CONTINUE READING
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