A comparison of the main structures of N-glycans of porcine islets with those from humans.

@article{Miyagawa2014ACO,
  title={A comparison of the main structures of N-glycans of porcine islets with those from humans.},
  author={Shuji Miyagawa and Akira Maeda and Takuji Kawamura and Takehisa Ueno and Noriaki Usui and Sachiko Kondo and Shinichi Matsumoto and Teru Okitsu and Masafumi Goto and Hiroshi Nagashima},
  journal={Glycobiology},
  year={2014},
  volume={24 2},
  pages={125-38}
}
After producing α1-3-galactosyltransferase knockout (GKO) pigs, most of the organs of these pigs showed less antigenicity to the human body. However, wild-type adult pig islets (API) that originally contained negligible levels of α-galactosidase now showed a clear antigenicity to human serum. In this study, N-glycans were isolated from both APIs and human islets. Their structures were then analyzed by a mapping technique based on their high-performance liquid chromatography elution positions… CONTINUE READING