A comparison of the inhibition of phosphodiesterase activity and allergic histamine release by disodium cromoglycate and compound I.C.I. 74917.

@article{BarrettBee1976ACO,
  title={A comparison of the inhibition of phosphodiesterase activity and allergic histamine release by disodium cromoglycate and compound I.C.I. 74917.},
  author={K. Barrett-Bee and W. Henderson},
  journal={Biochemical Society transactions},
  year={1976},
  volume={4 4},
  pages={
          699-701
        }
}
Compounds that increase cellular cyclic AMP concentrations, such as isoprenaline, adrenaline and prostaglandin El, inhibit the release of histamine from sensitive tissues after antigen challenge (Assem & Schild, 1969; Lichtenstein & Margolis, 1968). The present paper describes experiments that show that I.C.I. compound 74917, Bufrolin (6-n-butyl-2,8-dicarboxy-4,10-dioxo-1,4,7,1O-tetrahydro-l,7-phenanthroline), an antiallergic compound approximately 100 times as potent as disodium cromoglycate… Expand
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