A comparison of the inflammatory response of the lung to inhaled versus instilled particles in F344 rats.

@article{Henderson1995ACO,
  title={A comparison of the inflammatory response of the lung to inhaled versus instilled particles in F344 rats.},
  author={Rogene F. Henderson and Kevin E. Driscoll and Jack R. Harkema and Robert C. Lindenschmidt and Ian Chang and Kirk R. Maples and Edward B. Barr},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1995},
  volume={24 2},
  pages={
          183-97
        }
}
The potential pulmonary toxicity of poorly soluble airborne dusts generated in industrial and environmental settings is often evaluated by inhalation studies in rodents. Studies using intratracheal instillation of particles have been suggested as a less expensive alternative. We conducted a study to compare the inflammatory response of the lung to instilled versus inhaled particles. In one study, female F344/N rats, 11-13 weeks of age, were exposed for 6 hr/day, 5 days/week for 4 weeks by… CONTINUE READING

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