A comparison of the hypotensive and hypoglycaemic actions of an angiotensin converting enzyme inhibitor, an AT1a antagonist and troglitazone.

@article{Chen1996ACO,
  title={A comparison of the hypotensive and hypoglycaemic actions of an angiotensin converting enzyme inhibitor, an AT1a antagonist and troglitazone.},
  author={Shi-jian Chen and Yuichi Noguchi and Taro Izumida and Junko Tatebe and Shigehiro Katayama},
  journal={Journal of hypertension},
  year={1996},
  volume={14 11},
  pages={1325-30}
}
OBJECTIVE To define the relationship between changes in insulin sensitivity and attenuation of hypertension. METHODS We investigated whether troglitazone (CS-045, an insulin sensitizer) has an antihypertensive effect in fructose (FRU)-fed Wistar rats with insulin resistance and simultaneously compared its hypotensive efficacy with those of alacepril (ALA, an angiotensin converting enzyme inhibitor) and TCV-116 (an AT1a receptor antagonist). Male rats aged 8 weeks were divided into five groups… CONTINUE READING