A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain

@article{Ward1996ACO,
  title={A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain},
  author={Louise Ward and Ellen Wright and Stephen B. McMahon},
  journal={Pain},
  year={1996},
  volume={64},
  pages={129-138}
}
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134 Citations
Highly Influential Citations
3
Background Citations
47
Methods Citations
2
Results Citations
2

134 Citations

Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans.

TLDR
Cold-induced counter-irritation had an inhibitory effect on histaminergic itch, suggesting that agonists of cold transduction receptors could be of potential antipruritic value.

Effects of scratching and other counterstimuli on responses of trigeminothalamic tract neurons to itch-inducing stimuli in rats.

TLDR
It is found that scratching had little, if any, effect on baseline firing levels but greatly reduced mean pruriceptive firing following scratching for nearly 1 min, and none of the other noxious or innocuous counterstimuli significantly inhibited prurICEptive responses.

Complex interactions between pain and itch

Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.

TLDR
It is concluded that the STT neurons in the authors' sample are more likely to contribute to pain, allodynia, and hyperalgesia than to itch and alloknesis.

A literature review on the pharmacological sensitivity of human evoked hyperalgesia pain models.

TLDR
The present literature review aimed to provide insight into the sensitivity of different hyperalgesia and allodynia models of pharmacological treatment and raised questions about the translatability of these models to the treatment of neuropathic pain.

Effects of Short-term Temperature Change in the Innocuous Range on Histaminergic and Non-histaminergic Acute Itch.

TLDR
Investigation of the effect of alternating short-term temperature changes in the innocuous range on histamine and cowhage-induced acute itch indicates that cooling the skin to the cold threshold causes a temporary increase in the intensity of histamine-induced itch.

Interaction between histamine‐induced itch and experimental muscle pain

Electrically Evoked Itch in Human Subjects

TLDR
The electrical stimulation paradigms which were used to evoke itch in humans in the past are reviewed and recent attempts to explore electrically induced itch in atopic dermatitis patients are evaluated.

Noxious heat and scratching decrease histamine-induced itch and skin blood flow.

TLDR
It is suggested that heat pain and scratching may inhibit itch through a neurogenic mechanism that also affects skin blood flow.

Transcutaneous Slowly Depolarizing Currents Elicit Pruritus in Patients with Atopic Dermatitis.

TLDR
Results indicate a reduced adaptation of peripheral C-fibres conveying itch in patients with AD, and sensitized spinal itch processing may underlie chronic itch in these patients, who might benefit from centrally acting antipruritic therapy.
...

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