A comparison of the effects of intravenous infusion of individual branched-chain amino acids on blood amino acid levels in man.

  title={A comparison of the effects of intravenous infusion of individual branched-chain amino acids on blood amino acid levels in man.},
  author={S. Eriksson and L. Hagenfeldt and J. Wahren},
  journal={Clinical science},
  volume={60 1},
1. Intravenous infusions of L-valine (600 mumol/min), L-isoleucine (150 mumol/min), L-leucine (300 mumol/min) and a mixture of the three branched-chain amino acids (70% L-leucine, 20% L-valine, 10% L-isoleucine; 270 mumol/min) were given to four groups of healthy volunteer subjects. Whole-blood concentrations of amino acids and glucose and serum insulin were measured before and during the infusions. 2. Valine and isoleucine infusions resulted in twelve- and six-fold increases in the respective… Expand
Influence of leucine infusion on intracellular amino acids in humans
It can be calculated that approximately 40% of the leucine taken up by muscle was accumulated in the intracellular free pool, some 20% could have been incorporated into protein and 40% was probably oxidized. Expand
Influence of branched-chain amino acid infusion on arterial concentrations and brain exchange of amino acids in patients with hepatic cirrhosis
Patients with hepatic cirrhosis show a decreased whole blood concentration of aspartate indicating a reduced intracellular concentration of this amino acid, and the brain uptake of tyrosine and fractional uptake of leucine and valine is augmented in patients with hepatitis, demonstrating abnormal brain amino acid uptake in this disorder. Expand
Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man.
It is suggested that in normal man branched-chain amino acid infusion suppresses skeletal muscle proteolysis independently of any rise of plasma insulin, and an increase in muscle brANChed- chain amino acid concentrations and/or local brancher amino acid oxidation must account for the increased disposal of branchers amino acids. Expand
Branched-chain amino acid interactions with reference to amino acid requirements in adult men: valine metabolism at different leucine intakes.
Findings support the previously suggested mean valine requirement estimate of approximately 20 mg, which was suggested after six young adult men received four L-amino acid-based diets for 5 d supplying either 20 or 10 mg valine in combination with leucine. Expand
Bolus ingestion of individual branched-chain amino acids alters plasma amino acid profiles in young healthy men
It is suggested that plasma leucine is a regulator of the plasma concentrations of BCAAs, methionine and aromatic amino acids, as well as other plasma amino acid profiles in young healthy men. Expand
Oral branched-chain amino acids decrease whole-body proteolysis.
The results suggest that branched-chain amino acid ingestion suppresses whole-body proteolysis in tissues other than skeletal muscle in normal men. Expand
Regulation of the plasma amino acid profile by leucine via the system L amino acid transporter
It is suggested that leucine regulates the plasma concentrations of branched-chain amino acids, methionine, phenylalanine, and tyrosine and that system L amino acid transporters are involved in the leucines action. Expand
Is Intravenous Administration of Branched Chain Amino Acids Effective in the Treatment of Hepatic Encephalopathy? A Multicenter Study
It is concluded that BCAA adminstration, in the dose and composition employed in the present study, reduces the concentrations of aromatic amino acids but neither improves cerebral function nor decreases mortality in patients with hepatic encephalopathy. Expand
Leucine and tissue distribution of bulky and small neutral amino acids in rats: Dissociation between transport and insulin-mediated effects
SummaryThe mechanism of the observed decrease in the plasma concentration of several amino acids in the presence of high levels of Leu has remained unexplained. In the present study a decrease in theExpand
Overnight branched-chain amino acid infusion causes sustained suppression of muscle proteolysis.
Overnight BCAA infusion increased plasma BCAA concentrations by fivefold to eightfold, and this was associated with a 20% to 60% decline in arterial concentrations of other amino acids, and forearm Leu Ra was not reproducibly affected by infused BCAA. Expand


Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects.
The marked reduction in the concentrations of the aromatic amino acids, the uptake ofLeucine by the brain and the inhibition of brain methionine uptake, which accompany leucine infusion in healthy subjects, may be of relevance for the treatment of patients with portal-systemic encephalopathy. Expand
Serum amino acids in hepatic encephalopathy--effects of branched chain amino acid infusion on serum aminogram.
Encephalopathic patients with cirrhosis of the liver consistently showed elevated levels of the aromatic amino acids, phenylalanine, tyrosine and free tryptophan as well as methionine in serum,Expand
Effect of starvation on the turnover and metabolic response to leucine.
  • R. Sherwin
  • Medicine, Chemistry
  • The Journal of clinical investigation
  • 1978
Infusion of exogenous leucine in prolonged fasting results in a decline in plasma levels of other amino acids, improvement in nitrogen balance and unchanged excretion of 3-methylhistidine, thus suggesting stimulation of muscle protein synthesis. Expand
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection.
  • W. Oldendorf
  • Chemistry, Medicine
  • The American journal of physiology
  • 1971
Saturability of D-glucose uptake was demonstrated and evidence presented that all of the five hexoses measurably taken up by brain shared a common carrier, two blood-brain barrier carrier systems for amino acids. Expand
The time course of uptake of a series of natural and synthetic amino acids of the neutral group is studied in order to define the nature of the structural effects of these structural effects on the erythrocyte. Expand
Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.
Leucine, isoleucaine, and valine appear responsible for the effects of plasma amino or isoleucine andValine together, also were able to inhibit protein degradation and promote synthesis and five times normal plasma concentrations of the amino acids had larger effects. Expand
Altered clearance of free amino acids from plasma of patients with cirrhosis of the liver.
Summary Oral feeding of an egg-protein mixture or infusion of a balanced solution of essential amino acids to well-compensated cirrhotic patients is followed by a significant change in the rate ofExpand
The movement of amino acids between blood and skeletal muscle in the rat
1. The rates of entry of twenty of the blood amino acids into skeletal muscle of living rats were measured directly by means of a technique which ensured that a steady concentration of aExpand
Statistical methods
The stimulation of insulin release by essential amino acids from rabbit pancreas in vitro.
  • R. Milner
  • Biology, Medicine
  • The Journal of endocrinology
  • 1970