Corpus ID: 44333757

A comparison of the effects of caffeine, 8-cyclopentyltheophylline, and alloxazine on sleep in rats. Possible roles of central nervous system adenosine receptors.

@article{Virus1990ACO,
  title={A comparison of the effects of caffeine, 8-cyclopentyltheophylline, and alloxazine on sleep in rats. Possible roles of central nervous system adenosine receptors.},
  author={R. M. Virus and S. Ticho and M. Pilditch and M. Radulova{\vc}ki},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={1990},
  volume={3 4},
  pages={
          243-9
        }
}

R. M. Virus, S. Ticho, +1 author M. Radulovački

Published 1990

Chemistry, Medicine

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

The dose-response effects of administration of 8-cyclopentyltheophylline (CPT) (10, 20, and 40 mg/kg intraperitoneally [IP]) and alloxazine (ALX) (12.5, 25, and 50 mg/kg, IP) on sleep and wakefulness in rats were examined and compared to those of caffeine (12.5 mg/kg IP). Both CPT and ALX injected individually produced sleep suppression qualitatively similar to that produced by caffeine, but of a lower magnitude. However, when 20 mg/kg CPT and 50 mg/kg ALX were injected together, their sleep… CONTINUE READING

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