A comparison of the discriminative stimulus effects of delta(9)-tetrahydrocannabinol and O-1812, a potent and metabolically stable anandamide analog, in rats.

@article{Wiley2004ACO,
  title={A comparison of the discriminative stimulus effects of delta(9)-tetrahydrocannabinol and O-1812, a potent and metabolically stable anandamide analog, in rats.},
  author={Jenny L Wiley and Kari L Lavecchia and Natalie E Karp and Sanjitha Kulasegram and Anu Mahadevan and Raj K. Razdan and Billy R. Martin},
  journal={Experimental and clinical psychopharmacology},
  year={2004},
  volume={12 3},
  pages={173-9}
}
Efforts to determine whether Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and anandamide elicit similar discriminative stimulus effects have yielded conflicting results. The difficulty in establishing a discriminative cue to anandamide may be due to its metabolic instability. Rats were trained to discriminate either Delta(9)-THC or O-1812, a metabolically stable anandamide analog, from vehicle to avoid this issue. O-1812 and Delta(9)-THC substituted for each other; however, both drugs were more… CONTINUE READING

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