A comparison of the central nervous system effects of haloperidol, chlorpromazine and sulpiride in normal volunteers.

@article{McClelland1990ACO,
  title={A comparison of the central nervous system effects of haloperidol, chlorpromazine and sulpiride in normal volunteers.},
  author={G. R. McClelland and Sian M Cooper and Amanda Pilgrim},
  journal={British journal of clinical pharmacology},
  year={1990},
  volume={30 6},
  pages={795-803}
}
1. Twelve healthy male volunteers participated in four experimental occasions during each of which they were dosed with one of the following anti-psychotic drugs: chlorpromazine (50 mg), haloperidol (3 mg), sulpiride (400 mg) and placebo. Drugs were allocated to subjects in a double-blind, crossover fashion. 2. The subject's mood state, psychometric performance and electroencephalogram (EEG) were assessed pre-dose, and at 2, 4, 6, 8, 24 and 48 h post-dose. Mood states were assessed using 16… CONTINUE READING

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