A comparison of the binding of methylated cap analogues to wheat germ protein synthesis initiation factors 4F and (iso)4F.

@article{Carberry1991ACO,
  title={A comparison of the binding of methylated cap analogues to wheat germ protein synthesis initiation factors 4F and (iso)4F.},
  author={S E Carberry and Edward Darzynkiewicz and Dixie J Goss},
  journal={Biochemistry},
  year={1991},
  volume={30 6},
  pages={1624-7}
}
The binding of the 5'-terminal cap analogues m7GpppG and m7GTP to wheat germ protein synthesis initiation factors eIF-4F and eIF-(iso)4F as a function of pH, ionic strength, and temperature is described. Equilibrium binding data indicate that eIF-4F and eIF-(iso)4F have different mechanisms for interacting with the 5'-cap structure, but the complexes formed between m7GpppG and wheat germ factor eIF-(iso)4F more closely resemble complexes formed between this cap analogue and either mammalian eIF… CONTINUE READING

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