A comparison of the binding of drugs to adult and cord plasma

  title={A comparison of the binding of drugs to adult and cord plasma},
  author={Albert W. Pruitt and Peter G Dayton},
  journal={European Journal of Clinical Pharmacology},
The binding of diphenylhydantoin, imipramine, diazoxide, cephalothin and cephaloglycin to adult and cord plasma is compared. The free (unbound) fraction of diphenylhydantoin, imipramine and diazoxide in cord plasma is greater than in adult plasma. Although total protein concentration of cord plasma is significantly lower than in adult plasma, this does not satisfactorily explain the lesser binding of these drugs to cord plasma. 

From This Paper

Figures, tables, and topics from this paper.
5 Citations
13 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 13 references

The entry , accumulation and binding of diphenylhydantoin2 - C ~ a in brain

  • H. Fi remark, C. F. Barlow, L. J. Roth
  • Int . J . l ~ europharmacol .
  • 1970

Pre - para t ion and properties of serum and plasma proteins

  • E. J. Cotm, L. E. Strong, +4 authors H. L. Taylor
  • IV . J . Amer . chem . See .
  • 1969

Vereinfachte photometrische Methoden zur Bestirnmung des Blutbil irubins

  • L. Jendrassik, P. Grof
  • Bio - chem . Zeit .
  • 1969

P lasma protein binding of diphenylhydantoin in normal and hyperbil i rubinemic infants

  • P. K. M. Lunde, S. J. Yaffe
  • J . Pedlar .
  • 1968

Placental t ransfer of imipramine , a basic , lipid - soluble drug

  • B. H. Douglas, A. S. I-Iume
  • Amer . J . Obstet . Gynec .
  • 1968

Al tera t ion in metabol ism of acetylsalicylie acid in children with Down ' s syndrome : Decreased plasma binding and formation of salicyluric acid

  • M. S. Ebad, R. B. Kugel
  • Pedlar . Res .
  • 1967

The binding of drugs by plasma proteins

  • M. C. Meyer, D. E. Gut tman
  • J . Pharm . Sci .
  • 1961

Similar Papers

Loading similar papers…