A comparison of substance P peptide and preprotachykinin mRNA levels during development of rat medullary raphe and neostriatum

@article{Walker1991ACO,
  title={A comparison of substance P peptide and preprotachykinin mRNA levels during development of rat medullary raphe and neostriatum},
  author={Paul D. Walker and Todd L. Green and G. Miller Jonakait and Ronald P. Hart},
  journal={International Journal of Developmental Neuroscience},
  year={1991},
  volume={9},
  pages={47-55}
}
Substance P (SP) and the mRNA coding for its precursor peptide, preprotachykinin (PPT), were measured in medullary raphe nuclei (MRN) and neostriatum (NS) over development in order to determine (1) whether PPT mRNA levels correlate with peptide development, and (2) whether changes in PPT mRNA might help to account for the apparent decline in SP seen immunohistochemically in certain brain areas postnatally. Total RNA was quantified in dissected tissue pieces using the sensitive orcinol reaction… CONTINUE READING

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