A comparison of striatal and mesolimbic dopamine function in the rat during 6-month trifluoperazine administration

@article{Clow1980ACO,
  title={A comparison of striatal and mesolimbic dopamine function in the rat during 6-month trifluoperazine administration},
  author={Angela Clow and Andreas Theodorou and P Feroz Jenner and C. David Marsden},
  journal={Psychopharmacology},
  year={1980},
  volume={69},
  pages={227-233}
}
Previous work has shown that 6–12 months continuous trifluoperazine (TFP) administration to rats causes striatal dopamine receptor supersensitivity. We have now replicated our original findings in the striatum and report concurrent changes in mesolimbic dopamine function during chronic TFP (2.8–4.0 mg/kg/day) administration for 6 months. Initial inhibition of apomorphine-induced stereotyped behaviour, which lasted for 2 weeks after the beginning of drug administration, was replaced by an… CONTINUE READING