A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning

@article{Bradberry2009ACO,
  title={A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning},
  author={S. Bradberry and A. Vale},
  journal={Clinical Toxicology},
  year={2009},
  volume={47},
  pages={841 - 858}
}
Introduction. This article reviews the experimental and clinical studies that have compared the efficacy (impact on urine lead excretion, blood and tissue lead concentrations, resolution of features and survival) of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning. It also summarizes the pharmacokinetic and pharmacodynamic aspects and the adverse effects of treatment. Methods. Medline, Toxline, and Embase were searched for all… Expand
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TLDR
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Lead and mercury
TLDR
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Chelator combination as therapeutic strategy in mercury and lead poisonings
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Modelling dimercaptosuccinic acid (DMSA) plasma kinetics in humans
TLDR
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Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead
TLDR
A model to predict the effect of succimer (dimercaptosuccinic acid; DMSA) chelation therapy on blood lead concentrations and the pattern of urine lead excretion was successfully predicted in some patients, while poorly predicted in others. Expand
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