A comparison of six statins on the development of intimal hyperplasia in a human vein culture model.

@article{Corpataux2005ACO,
  title={A comparison of six statins on the development of intimal hyperplasia in a human vein culture model.},
  author={J. M. Corpataux and Jagjeeth B Naik and Karen E Porter and Nicholas J. M. London},
  journal={European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery},
  year={2005},
  volume={29 2},
  pages={177-81}
}
OBJECTIVE Intimal hyperplasia (IH) threatens the patency of up to 35% of saphenous vein (SV) bypass grafts. In addition to reducing cholesterol levels, statins may modulate smooth muscle cell proliferation and migration. Statins inhibit matrix metalloproteinase (MMP) activity. We therefore investigated the effect of six statins on neointimal formation and MMP activity in human SV organ culture. STUDY DESIGN Human SV specimens were cultured for 14 days in the presence of six different statins… CONTINUE READING

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