A comparison of simple allometric and maturation models for the prediction of morphine clearance in pediatrics.


BACKGROUND The objective of this study is to predict morphine clearance in children (preterm neonates to 10-month-old infants) by maturation models that include age and weight and to compare the predictive performance of morphine maturation models with simple allometric models. METHODS Age, weight, and morphine clearance data were obtained from the… (More)
DOI: 10.1515/DMDI.2011.103