A comparison of response to cisplatin, radiation and combined treatment for cells deficient in recombination repair pathways.

@article{Raaphorst2005ACO,
  title={A comparison of response to cisplatin, radiation and combined treatment for cells deficient in recombination repair pathways.},
  author={Gijsbert Peter Raaphorst and Maude Leblanc and Long Li},
  journal={Anticancer research},
  year={2005},
  volume={25 1A},
  pages={53-8}
}
The responses of cells with mutated DNA repair pathways were compared for cisplatin, radiation and combination treatments. The knockout of the nonhomologous endjoining (NHEJ) pathway resulted in increased radiation sensitivity, but no change in cisplatin response in the mouse cells and increased radiosensitivity but decreased cisplatin sensitivity in chicken cells. The mutation of the homologous recombination repair (HR) pathway through XRCC3 in CHO cells resulted in increased radiation and… CONTINUE READING
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