A comparison of random sequence reads versus 16S rDNA sequences for estimating the biodiversity of a metagenomic library

@inproceedings{Manichanh2008ACO,
  title={A comparison of random sequence reads versus 16S rDNA sequences for estimating the biodiversity of a metagenomic library},
  author={Chaysavanh Manichanh and Charles E. Chapple and L. Frangeul and Karine Gloux and Roderic Guig{\'o} and Jo{\"e}l Dore},
  booktitle={Nucleic acids research},
  year={2008}
}
The construction of metagenomic libraries has permitted the study of microorganisms resistant to isolation and the analysis of 16S rDNA sequences has been used for over two decades to examine bacterial biodiversity. Here, we show that the analysis of random sequence reads (RSRs) instead of 16S is a suitable shortcut to estimate the biodiversity of a bacterial community from metagenomic libraries. We generated 10,010 RSRs from a metagenomic library of microorganisms found in human faecal samples… CONTINUE READING

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