A comparison of plasma alprazolam concentrations following different routes of chronic administration in the Sprague-Dawley rat: implications for psychotropic drug research

@article{Skelton2000ACO,
  title={A comparison of plasma alprazolam concentrations following different routes of chronic administration in the Sprague-Dawley rat: implications for psychotropic drug research},
  author={Kelly H. Skelton and Charles B. Nemeroff and Michael J. Owens},
  journal={Psychopharmacology},
  year={2000},
  volume={151},
  pages={72-76}
}
Rationale: Benzodiazepines are effective in the treatment of anxiety disorders over a prolonged period of time. This results in relatively stable plasma concentrations over the course of a day. However, due to differences in drug clearance in rats, which generally metabolize and clear drugs much more rapidly than humans, it is difficult to model this steady level in rats. Objectives: Several methods of chronic alprazolam administration were compared to determine which would best result in… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Modification of the Bio Rad tricyclic antidepressant methodology to measure the serotonin reuptake inhibitors

  • JC Ritchie, W Zhang
  • Clin Chem
  • 1996

Recent developments in the psychopharmacology of anxiety disorders

  • RB Lydiard, O Brawmen-Mintzer, JC Ballenger
  • J Consult Clin Psychol
  • 1996

Extrapolation of toxicological and pharmacological data from animals to humans

  • WR Chappell, J Mordenti
  • Adv Drug Res
  • 1991

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