A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia
@article{Vase2002ACO, title={A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia}, author={Lene Vase and Joseph L. Riley and Donald D. Price}, journal={Pain}, year={2002}, volume={99}, pages={443-452} }
388 Citations
Factors contributing to large analgesic effects in placebo mechanism studies conducted between 2002 and 2007
- PsychologyPAINĀ®
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Conceptualizations and Magnitudes of Placebo Analgesia Effects Across Meta-Analyses and Experimental Studies
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The Placebo Analgesic Effect in Healthy Individuals and Patients: A Meta-Analysis
- Medicine, PsychologyPsychosomatic medicine
- 2017
It is suggested that patients benefited from placebo treatment to a greater degree than healthy individuals did and that studies on healthy individuals may underestimate the magnitude of the placebo analgesic effect in patients.
The magnitude of placebo analgesia effects depends on how they are conceptualized.
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The important reduction in placebo analgesia in low back pain after the single pre-exposure to the ineffective control treatment suggests the additional involvement of highly flexible mechanisms that may counteract the pro-analgesic effects of expectations.
Predictors of the placebo analgesia response in randomized controlled trials of chronic pain: a meta-analysis of the individual data from nine industrially sponsored trials
- Medicine, PsychologyPain
- 2015
It is thought that patients' perception of treatment allocation and expectations toward treatment efficacy could potently predict outcomes of RCTs, supporting the expectancy hypothesis.
New insights into placebo analgesia
- Medicine, PsychologyCurrent opinion in anaesthesiology
- 2003
The understanding of the placebo effect may lead to better design of clinical trials and better medical practice, as it can be used in therapeutic protocols aimed at reducing drug intake.
Nocebo vs. Placebo: The Challenges of Trial Design in Analgesia Research
- PsychologyClinical pharmacology and therapeutics
- 2015
It is explained how recent placebo and nocebo studies of effects of verbal suggestion, expectancy, and emotions may improve understanding and discussion of increasing placebo effects, account/control for large parts of the variability of placebo effects and suggest ways to improve blinding in future trials.
The placebo response in clinical trials: more questions than answers
- Psychology, MedicinePhilosophical Transactions of the Royal Society B: Biological Sciences
- 2011
This work addresses the placebo response rate outside the laboratory and outside of trials in clinical routine, and poses a serious challenge whether the drug response in trials can be taken as evidence of drug effects in clinicaloutine.
Consideration in Randomized Placebo-Controlled Trial on Neck Pain to Avoid the Placebo Effect in Analgesic Action
- Medicine, PsychologyFrontiers in Pharmacology
- 2022
Logistic regression analysis finds neck pain patients with shorter disease duration are more likely to overscore their pain severity, because of their less experience in pain perception, tolerance, and analgesia expectation.
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