A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia

  title={A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia},
  author={Lene Vase and Joseph L. Riley and Donald D. Price},

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The Placebo Analgesic Effect in Healthy Individuals and Patients: A Meta-Analysis
It is suggested that patients benefited from placebo treatment to a greater degree than healthy individuals did and that studies on healthy individuals may underestimate the magnitude of the placebo analgesic effect in patients.
The magnitude of placebo analgesia effects depends on how they are conceptualized.
Direct Comparison of Placebo Effects on Clinical and Experimental Pain
The important reduction in placebo analgesia in low back pain after the single pre-exposure to the ineffective control treatment suggests the additional involvement of highly flexible mechanisms that may counteract the pro-analgesic effects of expectations.
Predictors of the placebo analgesia response in randomized controlled trials of chronic pain: a meta-analysis of the individual data from nine industrially sponsored trials
It is thought that patients' perception of treatment allocation and expectations toward treatment efficacy could potently predict outcomes of RCTs, supporting the expectancy hypothesis.
New insights into placebo analgesia
The understanding of the placebo effect may lead to better design of clinical trials and better medical practice, as it can be used in therapeutic protocols aimed at reducing drug intake.
Nocebo vs. Placebo: The Challenges of Trial Design in Analgesia Research
It is explained how recent placebo and nocebo studies of effects of verbal suggestion, expectancy, and emotions may improve understanding and discussion of increasing placebo effects, account/control for large parts of the variability of placebo effects and suggest ways to improve blinding in future trials.
The placebo response in clinical trials: more questions than answers
This work addresses the placebo response rate outside the laboratory and outside of trials in clinical routine, and poses a serious challenge whether the drug response in trials can be taken as evidence of drug effects in clinicaloutine.
Consideration in Randomized Placebo-Controlled Trial on Neck Pain to Avoid the Placebo Effect in Analgesic Action
Logistic regression analysis finds neck pain patients with shorter disease duration are more likely to overscore their pain severity, because of their less experience in pain perception, tolerance, and analgesia expectation.


Partial antagonism of placebo analgesia by naloxone
Influence of the method of drug administration on analgesic response
This study underscores the power of the placebo and emphasizes that even the most subtle cues can elicit a placebo response.
A study of the placebo response.
Placebo and naloxone can alter post-surgical pain by separate mechanisms
Evidence is reported that placebo analgesia can occur after blockade of opioid mechanisms by naloxone and that n aloxone can produce hyperalgesia independent of the placebo effect.
Conditioned placebo responses.
It is suggested that placebo responses are conditionable in the laboratory in both a positive and negative direction.