A comparison of paroxetine and placebo in depressed outpatients.

@article{Dunbar1993ACO,
  title={A comparison of paroxetine and placebo in depressed outpatients.},
  author={G. C. Dunbar and James L. Claghorn and Ari Kiev and Karl E. Rickels and W. Tyler Smith},
  journal={Acta psychiatrica Scandinavica},
  year={1993},
  volume={87 5},
  pages={302-5}
}
To compare the safety and efficacy of paroxetine (n = 167) and placebo (n = 169), data from 4 centres using the same protocol were pooled. A double-blind parallel group design was used, with therapy lasting 6 weeks. Significant differences between paroxetine- and placebo-treated patients were found on the major efficacy outcome variables by week 2 and on all efficacy variables by week 4 of the study. Improvement on the sleep factor of the Hamilton Rating Scale for Depression was found after 7 d… CONTINUE READING

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