A comparison of paroxetine, imipramine and placebo in depressed out-patients.

@article{Dunbar1991ACO,
  title={A comparison of paroxetine, imipramine and placebo in depressed out-patients.},
  author={G. C. Dunbar and Jason Cohn and Louis F Fabre and John P. Feighner and Ronald R. Fieve and Joseph Mendels and Ram K. Shrivastava},
  journal={The British journal of psychiatry : the journal of mental science},
  year={1991},
  volume={159},
  pages={
          394-8
        }
}
To compare the safety and antidepressant efficacy of paroxetine, imipramine, and placebo, data from six centres using the same protocol were pooled. A double-blind parallel-group design was used, with therapy lasting six weeks. From week 2 onwards, both the 240 paroxetine-treated and the 237 imipramine-treated patients were significantly different from the 240 placebo-treated patients, but no different from each other. Side-effects with paroxetine were less likely to lead to drop-out than with… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
31 Citations
16 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 16 references

A review of the metabolism and pharmacokinetics of paroxetine in man

  • P F.
  • Ada PsychiatricaScandinavica,
  • 1989
1 Excerpt

Relation betweenyawningbehaviourand central serotonergicneuronal system in rats

  • P. RAPTOPOULUS, G. R. MCCLELLAND, D. JACKSON
  • Archives of Pharmacology
  • 1989

The effect of paroxetine on the quantitativeEEG

  • S. A. MoNToouEJtY, M. ASBERO
  • Acta PsychiatricaScandinavica
  • 1989

Bio chemical effect of the antidepressant paroxetine, a specific 54fF (hydroxytryptamine) uptake

  • A M.
  • inhibitor. Psychopharmacology,
  • 1987
2 Excerpts

Changes in human whole blood 5 - HT and platelet 5 - HTduringtreatmentwithparostetine , a selective 5 - HT uptake inhibitor

  • V. MArriNo
  • Journal of Psychopharmacology
  • 1987

The effect of selective 5 - HT uptake inhibitors on 5 - methoxy - N , N dimethyltryptamine - inducedejaculationin the rat

  • D. R. THOMAS, D. R. Nascm
  • British Journal of Pharmacology
  • 1987

Similar Papers

Loading similar papers…