A comparison of paroxetine, imipramine and placebo in depressed out-patients.

  title={A comparison of paroxetine, imipramine and placebo in depressed out-patients.},
  author={G. C. Dunbar and Jason Cohn and Louis F Fabre and John P. Feighner and Ronald R. Fieve and Joseph Mendels and Ram K. Shrivastava},
  journal={The British journal of psychiatry : the journal of mental science},
To compare the safety and antidepressant efficacy of paroxetine, imipramine, and placebo, data from six centres using the same protocol were pooled. A double-blind parallel-group design was used, with therapy lasting six weeks. From week 2 onwards, both the 240 paroxetine-treated and the 237 imipramine-treated patients were significantly different from the 240 placebo-treated patients, but no different from each other. Side-effects with paroxetine were less likely to lead to drop-out than with… CONTINUE READING

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