A comparison of parametric and non-parametric approaches to target-controlled infusion of propofol.

@article{Crankshaw2010ACO,
  title={A comparison of parametric and non-parametric approaches to target-controlled infusion of propofol.},
  author={David P. Crankshaw and Mark D. J. Brown and Andrew Robin Bjorksten},
  journal={Anaesthesia and intensive care},
  year={2010},
  volume={38 3},
  pages={
          437-44
        }
}
Nineteen adult patients of either gender received intravenous infusions of propofol, scaled to estimated lean body mass (LBM), for 150 minutes as part of a balanced anaesthetic. Arterial blood was assayed for whole blood propofol. The first subject received propofol at a fixed rate of 0.058 mg x min(-1) x kg(LBM)(-1). Subsequent groups received variable rate infusions based on the ratio of the infusion rate to the propofol concentration at each sampling point in the previous group, multiplied… CONTINUE READING

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