A comparison of oral and intravenous indomethacin dispositions in the premature infant with patent ductus arteriosus.

@article{Evans1981ACO,
  title={A comparison of oral and intravenous indomethacin dispositions in the premature infant with patent ductus arteriosus.},
  author={Michael A. Evans and Rama Bhat and D. Vidyasagar and Milan V Patel and Alois R. Hastreiter},
  journal={Pediatric pharmacology},
  year={1981},
  volume={1 3},
  pages={251-8}
}
Plasma concentrations of indomethacin were studied in 18 premature infants exhibiting significant patent ductus arteriosus (sPDA) after either intravenous or oral drug administration. Oral absorption of indomethacin was prolonged and bioavailability, based on area under the curve (AUC), was less than 20%. The mean volume of distribution for indomethacin was 0.36 l/kg and showed only a small variation between subjects. The drug elimination half-life ranged from 10-25 hours and demonstrated a… CONTINUE READING