Corpus ID: 27866535

A comparison of nine local anesthetics.

  title={A comparison of nine local anesthetics.},
  author={H. S. Hamilton and B. A. Westfall and J. K. Ferguson},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={94 3},
  • H. S. Hamilton, B. A. Westfall, J. K. Ferguson
  • Published 1948
  • Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1. L.D. 50 values for procaine, metycaine, monocaine, naphthocaine, butacaine, octacaine, cocaine, pontocaine and nupercaine administered intraperitoneally in white mice, decrease in magnitude in the order given. Epinephrine hydrochloride in solution with each anesthetic increases the systemic toxicity of procaine and metycaine and decreases the toxicity of pontocaine and nupercaine significantly, but has no effect on the toxicity of the 5 other drugs tested. 2. Tissue toxicity in guinea pigs… CONTINUE READING
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