We compared the safety and effectiveness of oxytocin, dinoprostone and misoprostol for cervical priming. A total of 218 patients were enrolled to receive between one and three treatments according to physicians’ options. The end points were: (1) vaginal delivery or Bishop score ≥8 at the end of 12 h, (2) vaginal delivery by 12 h or difference ≥4 between the initial and 12th hour Bishop scores. Statistical analyses were performed with ANOVA, Krustal Wallis, Scheffe, χ², Fisher, Advanced χ², and Kolmogorov–Smirnov tests. Tukey’s HSD was used as a post hoc test. Misoprostol showed statistical significance for the rate of vaginal delivery <12 h, ≥8 Bishop score at the end of 12 h, and cervical change of ≥4 Bishop scores within 12 h (p = 0.013). Comparison between cases Bishop score <4 showed that misoprostol is more effective than dinoprostone and oxytocin. Considering Bishop score = 0 cases we calculated no statistical significance.