A comparison of misoprostol, controlled-release dinoprostone vaginal insert and oxytocin for cervical ripening

Abstract

We compared the safety and effectiveness of oxytocin, dinoprostone and misoprostol for cervical priming. A total of 218 patients were enrolled to receive between one and three treatments according to physicians’ options. The end points were: (1) vaginal delivery or Bishop score ≥8 at the end of 12 h, (2) vaginal delivery by 12 h or difference ≥4 between the initial and 12th hour Bishop scores. Statistical analyses were performed with ANOVA, Krustal Wallis, Scheffe, χ², Fisher, Advanced χ², and Kolmogorov–Smirnov tests. Tukey’s HSD was used as a post hoc test. Misoprostol showed statistical significance for the rate of vaginal delivery <12 h, ≥8 Bishop score at the end of 12 h, and cervical change of ≥4 Bishop scores within 12 h (p = 0.013). Comparison between cases Bishop score <4 showed that misoprostol is more effective than dinoprostone and oxytocin. Considering Bishop score = 0 cases we calculated no statistical significance.

DOI: 10.1007/s00404-011-1844-7

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@article{ilfeler2011ACO, title={A comparison of misoprostol, controlled-release dinoprostone vaginal insert and oxytocin for cervical ripening}, author={Dilek Benk Şilfeler and Bulent Tandogan and Habibe Ayvaci and Ibrahim Silfeler and Ilter Yenidede and Vedat Dayicioglu}, journal={Archives of Gynecology and Obstetrics}, year={2011}, volume={284}, pages={1331-1337} }