A comparison of methods to identify open-lung PEEP

Many methods exist in the literature for identifying PEEP to set in ARDS patients following a lung recruitment maneuver (RM). We compared ten published parameters for setting PEEP following a RM. Lung injury was induced by bilateral lung lavage in 14 female Dorset sheep, yielding a PaO2 100–150 mmHg at FIO2 1.0 and PEEP 5 cmH2O. A quasi-static P–V curve was… (More)