A comparison of methods for differential expression analysis of RNA-seq data

  title={A comparison of methods for differential expression analysis of RNA-seq data},
  author={Charlotte Soneson and Mauro Delorenzi},
  booktitle={BMC Bioinformatics},
Finding genes that are differentially expressed between conditions is an integral part of understanding the molecular basis of phenotypic variation. In the past decades, DNA microarrays have been used extensively to quantify the abundance of mRNA corresponding to different genes, and more recently high-throughput sequencing of cDNA (RNA-seq) has emerged as a powerful competitor. As the cost of sequencing decreases, it is conceivable that the use of RNA-seq for differential expression analysis… CONTINUE READING
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