A comparison of mass balance, pharmacokinetics and disposition of [14C(U)]- and [125I]recombinant human interleukin-2 in cynomolgus monkeys.

@article{Nadeau1995ACO,
  title={A comparison of mass balance, pharmacokinetics and disposition of [14C(U)]- and [125I]recombinant human interleukin-2 in cynomolgus monkeys.},
  author={R W Nadeau and Hiroya Satoh and S W Scheide and Robert M Crowl and Richard Conroy and William A. Garland and D J Liberato},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1995},
  volume={23 9},
  pages={904-9}
}
Recombinant human interleukin-2 (rHuIL-2) has been metabolically labeled with 14C amino acids in Escherichia coli and affinity purified on a rHuIL-2 receptor affinity column. The radiolabeled molecule had a specific radioactivity of 238 dpm/unit and the identical amino acid sequence and biological activity as unlabeled rHuIL-2. In this study, we used this labeled [14C(U)]rHuIL-2 and commercially available [125I]rHuIL-2 (identical in sequence to the [14C(U)]rHuIL-2) to compare the mass balance… CONTINUE READING