A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial.

@article{Yuen2008ACO,
  title={A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial.},
  author={Vivian Man Ying Yuen and Theresa W C Hui and Michael G Irwin and Man King Yuen},
  journal={Anesthesia and analgesia},
  year={2008},
  volume={106 6},
  pages={1715-21}
}
BACKGROUND Midazolam is the most commonly used premedication in children. It has been shown to be more effective than parental presence or placebo in reducing anxiety and improving compliance at induction of anesthesia. Clonidine, an alpha(2) agonist, has been suggested as an alternative. Dexmedetomidine is a more alpha(2) selective drug with more favorable pharmacokinetic properties than clonidine. We designed this prospective, randomized, double-blind, controlled trial to evaluate whether… CONTINUE READING