A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+.

@article{Pourahmad2000ACO,
  title={A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+.},
  author={Jalal Pourahmad and Peter James O'Brien},
  journal={Toxicology},
  year={2000},
  volume={143 3},
  pages={263-73}
}
The molecular cytotoxic mechanisms of hepatocyte cell death induced by CuCl2, an essential redox transition metal has been compared with CdCl2, an environmental toxin. The ED50 concentrations found for Cu2+ and Cd2+ (i.e. 50% membrane lysis in 2 h) were 50 and 20 microM respectively. However reactive oxygen species ('ROS') formation, GSH oxidation and lipid peroxidation were induced by Cu2+ at these concentrations much more rapidly than by Cd2+. The decline of mitochondrial membrane potential… CONTINUE READING
67 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 67 extracted citations

Similar Papers

Loading similar papers…