A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3

@article{Timmer1999ACO,
  title={A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3},
  author={Tineke Timmer and P. Terpstra and A. V. van den Berg and Patrick MJF Veldhuis and A. F. M. ter Elst and Gerassimos E Voutsinas and Miriam M F Hulsbeek and Tineke G Draaijers and Maaike W. G. Looman and Klaas Kok and S. L. Naylor and C. H. Buys},
  journal={European Journal of Human Genetics},
  year={1999},
  volume={7},
  pages={478-486}
}
In the search for a tumour suppressor gene in the 3p21.3 region we isolated two genes, RBM5 and RBM6. Gene RBM5 maps to the region which is homozygously deleted in the small cell lung cancer cell line GLC20; RBM6 crosses the telomeric breakpoint of this deletion. Sequence comparison revealed that at the amino acid level both genes show 30% identity. They contain two zinc finger motifs, a bipartite nuclear signal and two RNA binding motifs, suggesting that the proteins for which RBM5 and RBM6… CONTINUE READING
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Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes

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  • Adv Cancer Res
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Homology in the human genome between a 3p21.3 region and a region of Xp11.23 [Abstract

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