A comparison of factors associated with substance-induced versus independent depressions.

  title={A comparison of factors associated with substance-induced versus independent depressions.},
  author={Marc A. Schuckit and Tom L. Smith and George P. Danko and Juliann Pierson and Ryan S Trim and John I. Nurnberger and John Kramer and Samuel Kuperman and Laura J. Bierut and Victor M Hesselbrock},
  journal={Journal of studies on alcohol and drugs},
  volume={68 6},
OBJECTIVE This article expands on the results from a 1997 report from the Collaborative Study on the Genetics of Alcoholism (COGA), using a new phase of the protocol to evaluate the prevalence and characteristics of substance-induced and independent major depressive episodes (MDEs) in a population of alcoholics and nonalcoholics. METHOD Data were evaluated from Phase II of the six-center-wide COGA investigation using information gathered beginning in January 1997. Data were generated through… 

Tables from this paper

Subtypes of major depression in substance dependence.

Psychiatric measures were better predictors of MDE subtype than substance-related or socio-demographic ones and individuals with both types of Mde have greater psychiatric severity than those with I-MDE only or SI-Mde only.

Relationships among independent major depressions, alcohol use, and other substance use and related problems over 30 years in 397 families.

Data support the importance of distinguishing between IDE and substance-induced depressions when evaluating the relationship between AUDs and depression syndromes and suggest a link between IDEs and AUDs is weak.

Alcohol use, Abuse, Depression and Anxiety : The Clinical Links

Investigations of patient samples indicate a strong co-occurrence of alcoholism with diverse forms of anxiety and depressive disorders, and results from community surveys and epidemiologic samples indicate that substantial comorbidity also exists for these disorders in the general population.

Indexing the ‘dark side of addiction’: substance‐induced affective symptoms and alcohol use disorders

Affective symptoms are common in severe alcohol use disorders are associated with a history of independent affective/anxiety disorders, neuroticism and suicidal behaviors; and may promote further heavy drinking.

Pretreatment clinical and risk correlates of substance use disorder patients with primary depression.

The findings suggest that effectiveness of substance use interventions may be augmented with depression treatment for primary depression patients, given their more severe clinical presentation and vulnerability characteristics.

Alcohol Induced Depression: Clinical, Biological and Genetic Features

Clinical and biological features that may help physicians to identify AI-MD and improve its therapeutic approach are found and some suggestive variants were observed.

Correlation and characteristics of self-rating and clinically rating depression among alcoholics in the course of early abstinence.

The BDI could be a useful tool not only for routine screening and reassessment of depression, but also for exploring emotional content during early abstinence and planning tailored integrative therapy and relapse prevention for alcoholics.



Comparison of induced and independent major depressive disorders in 2,945 alcoholics.

The contention that it is possible to differentiate between what appear to be substance-induced and independent depressive episodes in alcoholics might be important for establishing prognosis and optimal treatment is supported.

A validity study of the SSAGA--a comparison with the SCAN.

Results from this study and two previous studies which examined reliability indicate that the SSAGA is a highly reliable and valid instrument for use in studies of a variety of psychiatric disorders, including alcohol and drug dependence.

Secondary depression in weaned alcoholics: implications of Lesch's typology of chronic alcoholism.

A potential guide to differentiate depressed alcoholic patients who might need specific treatment for depression could be the typology of Lesch et al .

Shared genetic risk of major depression, alcohol dependence, and marijuana dependence: contribution of antisocial personality disorder in men.

In this sample, the shared genetic risk between MD and both AD and MJD was largely explained by genetic effects on ASPD, which in turn was associated with increased risk of each of the other disorders.

Comorbidity of select anxiety and affective disorders with alcohol dependence in southwest California Indians.

The hypothesis that despite high rates of alcohol dependence, Southwest California Indians do not have higher rates of anxiety and affective disorders or comorbidity of these disorders with alcohol dependence than those reported in large surveys of non-American Indian populations is supported.

A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA.

Although SSAGA was designed to provide for broad phenotyping of alcoholism, review of its new features suggests its suitability for a variety of family studies, not just those focusing on substance abuse.

Diagnosis of Depression in Alcohol Dependence: Changes in Prevalence with Drinking Status

It is suggested that depression is largely associated with the episode of drinking which led to admission in patients who are dependent on alcohol and may be due to the effect of chronic alcohol intoxication.

One-year incidence rate of major depression and other psychiatric disorders in 239 alcoholic men.

Evaluating the incidence of new episodes of major depressive disorders among alcohol-dependent men during the year following treatment shows no evidence of an increased incidence of any other major psychiatric disorder and results are consistent with prospective studies of children of alcoholics and of longitudinal evaluations of general population samples.

Measurement of depression in alcoholics.

The Hamilton Depression Scale (Ham-D) showed high sensitivity, high specificity and good agreement with DSM-III diagnosis by clinical interview as the standard, and should be used instead of self-report scales in screening for depression among alcoholics.

Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions.

This large survey suggests a higher prevalence of major depressive disorder in the US population than large-sample estimates from the 1980s and 1990s and the shift in highest lifetime risk from young to middle-aged adults is an important transformation in the distribution of MDD.