A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation

@article{Dere2010ACO,
  title={A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation},
  author={Kamer Dere and Ilker Sucullu and Ersel Tan Budak and Suleyman Yeyen and Ali İlker Filiz and Sezai Ozkan and Guner Dagli},
  journal={European Journal of Anaesthesiology},
  year={2010},
  volume={27},
  pages={648–652}
}
Objective The intent of our study was to compare the effects of dexmedetomidine versus midazolam on perioperative hemodynamics, sedation, pain, satisfaction and recovery scores during colonoscopy. Material and methods A total of 60 ASA I–II patients, between 20 and 80 years of age were included in the study. Patients were randomly assigned to two groups. Midazolam 0.05 mg kg−1 and fentanyl citrate 1 μg kg−1 were administered intravenously to cases in Group I (n = 30). An initial loading dose of… 
A Comparison of Dexmedetomidine versus Propofol on Hypotension during Colonoscopy under Sedation
Background: Sedation for colonoscopy with propofol is often associated with decreasing in arterial blood pressure. Dexmedetomidine is a sedative drug with a highly selective alpha2 adrenoreceptor
Dexmedetomidine versus ketofol for moderate sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP) comparative study
Abstract Background Recently dexmedetomidine had been successfully used in conscious (moderate) sedation as a good competitive to popular agent (midazolam). Different concentrations of ketamine and
Dexmedetomidine versus ketofol for moderate sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP) comparative study
TLDR
Ketofol (1:1) provided better hemodynamic stability than dexmedetomidine and standard alternative to it in moderate sedation during ERCP and standard alternatives for patients’ and endoscopists’ satisfactions were compared.
To Compare the Effects of Dexmedetomidine and Midazolam for Conscious Sedation in Patients Undergoing Upper Gastrointestinal Endoscopic Procedures-an open labelled prospective study
Our aim was to compare the hemodynamic parameters, sedation profile, duration of procedure and recovery profile of intravenous Dexmedetomidine and Midazolam in patients undergoing upper
To Compare the Hemodynamic Changes with Single Dose of Intravenous Dexmedetomidine versus Midazolam: A Randomized, Prospective Study
TLDR
It is concluded that a single intravenous pre anesthetic dose of Dexmedetomidine of 0.6mcg/kg body weight blunts haemodynamic response of anesthetic and surgical stress more efficiently and maintain the intraoperative haemodynamics stability in comparison to 0.05mg/kg dose of midazolam.
Dexmedetomidine versus midazolam for conscious sedation in endoscopic retrograde cholangiopancreatography: An open-label randomised controlled trial
TLDR
Dexmedetomidine can be a superior alternative to midazolam for conscious sedation in ERCP and showed higher patient and surgeon satisfaction scores, according to the primary objective.
Dexmedetomidine-ketamine versus Dexmedetomidine-midazolam-fentanyl for monitored anesthesia care during chemoport insertion: a Prospective Randomized Study
TLDR
The DK and DMF groups showed comparable recovery time, onset time, cardiorespiratory variables, and analgesia, however, the DMF group showed a better sedation quality and satisfaction scores despite the lower infusion rate of dexmedetomidine, and a higher incidence of BIS < 60 than the DK group.
Dexmedetomidine versus midazolam for sedation in upper gastrointestinal endoscopy
TLDR
Dexmedetomidine has a good safety profile and is an effective sedative for use in upper gastrointestinal endoscopy and overall satisfaction was higher in the dexmedetamidine group than the midazolam group.
Efficacy of a Dexmedetomidine–Remifentanil Combination Compared with a Midazolam–Remifentanil Combination for Conscious Sedation During Therapeutic Endoscopic Retrograde Cholangio-Pancreatography: A Prospective, Randomized, Single-Blinded Preliminary Trial
TLDR
The dexmedetomidine–remifentanil protocol provided a parallel sedative efficacy and improved respiratory sparing effects and can be used safely as a conscious sedation method during ERCP.
A comparison of dexmedetomidine versus midazolam for sedation, hemodynamic and intraocular pressure response during cataract surgery under conscious sedation: A randomized, double-blind trial
TLDR
Dexmedetomidine is a good safety profile as compared to midazolam group and an effective sedative agent for use in cataract surgery.
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References

SHOWING 1-10 OF 24 REFERENCES
Sole Use of Dexmedetomidine Has Limited Utility for Conscious Sedation during Outpatient Colonoscopy
TLDR
The use of dexmedetomidine to provide analgesia/sedation for colonoscopy is limited by distressing side effects, pronounced hemodynamic instability, prolonged recovery, and a complicated administration regimen.
The comparison of dexmedetomidine and midazolam used for sedation of patients during upper endoscopy: A prospective, randomized study.
TLDR
Dexmedetomidine performed as effectively and safely as midazolam when used as a sedative in upper gastroscopy; it was superior to midAZolam with regard to retching, rate of side effects and endoscopist satisfaction.
Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes.
TLDR
DMED is a more highly selective alpha 2-adrenergic agonist than clonidine that has sedative, analgesic, and cardiovascular stabilizing qualities and was well tolerated in the healthy volunteers.
Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit
TLDR
In conclusion, dexmedetomidine is a useful agent for the provision of postoperative analgesia and sedation in patients requiring intensive care and could be predicted from the known properties of alpha‐2 agonists.
Comparison of dexmedetomidine–propofol vs. fentanyl–propofol for laryngeal mask insertion
TLDR
Dexmedetomidine, when used before propofol induction provides successful laryngeal mask insertion comparable to fentanyl, while preserving respiratory functions more than fentanyl.
Dexmedetomidine causes prolonged recovery when compared with midazolam/fentanyl combination in outpatient shock wave lithotripsy
Background and objectives: Analgesia and sedation are usually required during extracorporeal shock wave lithotripsy. In the present study, the recovery time and effectiveness of sedation and
Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and haemodynamic state.
TLDR
Comparing the perioperative metabolic and haemodynamic effects of two alpha 2-agonists, clonidine and the more selective dexmedetomidine, in 30 ASA I patients undergoing plastic surgical procedures under general anaesthesia found both decreased peri operative oxygen consumption effectively, with a similar haemodynamics profile.
Comparison of the effects of intravenous midazolam alone and in combination with meperidine on hemodynamic and respiratory responses and on patient compliance during upper gastrointestinal endoscopy: a randomized, double-blind trial.
TLDR
It is observed that heart rate increases significantly whereas SAP, DAP and SpO2 decrease significantly with both sedation methods and combined sedation in selected patients provides a safe sedation with a mild to moderate increase in heart rate and a better patient compliance during gastroscopy.
Dexmedetomidine Pharmacodynamics: Part I: Crossover Comparison of the Respiratory Effects of Dexmedetomidine and Remifentanil in Healthy Volunteers
TLDR
Compared with remifentanil, dexmedetomidine infusions did not result in clinically significant respiratory depression, decreased rather than increased the apnea/hypopnea index, and exhibited some similarity with natural sleep.
Pharmacokinetic and Pharmacodynamic Characteristics of Medications Used for Moderate Sedation
  • T. Gan
  • Medicine
    Clinical pharmacokinetics
  • 2006
TLDR
AQUAVAN® injection (fospropofol disodium), a phosphorylated prodrug of propofol, is an investigational agent possessing a unique and distinct pharmacokinetic and pharmacodynamic profile, associated with a slightly longer time to peak effect and a more prolonged pharmacodynamic effect.
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