A comparison of dense transposon insertion libraries in the Salmonella serovars Typhi and Typhimurium

@article{Barquist2013ACO,
  title={A comparison of dense transposon insertion libraries in the Salmonella serovars Typhi and Typhimurium},
  author={Lars Barquist and Gemma C. Langridge and D. Turner and M. Phan and A. Turner and A. Bateman and J. Parkhill and J. Wain and P. Gardner},
  journal={Nucleic Acids Research},
  year={2013},
  volume={41},
  pages={4549 - 4564}
}
Salmonella Typhi and Typhimurium diverged only ∼50 000 years ago, yet have very different host ranges and pathogenicity. Despite the availability of multiple whole-genome sequences, the genetic differences that have driven these changes in phenotype are only beginning to be understood. In this study, we use transposon-directed insertion-site sequencing to probe differences in gene requirements for competitive growth in rich media between these two closely related serovars. We identify a… Expand
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