A comparison of crypt-cell proliferation in rat colonic mucosa in vivo and in vitro.

@article{Finney1986ACO,
  title={A comparison of crypt-cell proliferation in rat colonic mucosa in vivo and in vitro.},
  author={Karen J. Finney and Paul Ince and D. R. Appleton and Johan Sunter and Amanda J. Watson},
  journal={Journal of anatomy},
  year={1986},
  volume={149},
  pages={177-88}
}
The successful development of a long-term organ culture system has made it possible to perform experiments on rat colonic mucosa in vitro. However, the effect of trauma or the withdrawal of trophic influences in culture may result in the disturbance of proliferation within the tissue. In this paper we describe an investigation designed to characterise the culture system by a comparison of the proliferative parameters in vitro with those in vivo. Stathmokinetic experiments were performed in vivo… CONTINUE READING