A comparison of continuous subcutaneous paliperidone infusion and repeated subcutaneous injection of risperidone free-base in rats.

@article{Marchese2010ACO,
  title={A comparison of continuous subcutaneous paliperidone infusion and repeated subcutaneous injection of risperidone free-base in rats.},
  author={Giorgio Marchese and B Pittau and Gianluca Casu and G Peddio and Gabriele Pinna Spada and Marilena Pira and Andrea Deriu and Filippo Portesani and Carla Pisu and Pierangelo Lazzari and L. Pani},
  journal={European psychiatry : the journal of the Association of European Psychiatrists},
  year={2010},
  volume={25 2},
  pages={92-100}
}
It is proposed that to achieve a therapeutic effect in schizophrenia patients, dopamine D(2)-receptor occupancy by antipsychotics within the striatum must exceed 60-65%. However, at high levels of D(2)-receptor occupancy, the risk of extrapyramidal symptoms (EPS) is increased. Following oral dosing of antipsychotics, peaks and troughs in plasma drug concentrations may be mirrored by fluctuations in D(2)-receptor occupancy. Paliperidone, a novel antipsychotic available as extended-release… CONTINUE READING