A comparison of cerebral ischemic flow thresholds during halothane/N2O and isoflurane/N2O anesthesia in rats.

@article{Verhaegen1992ACO,
  title={A comparison of cerebral ischemic flow thresholds during halothane/N2O and isoflurane/N2O anesthesia in rats.},
  author={M. J. A. Verhaegen and Michael M. Todd and David Sjoquist Nick Warner},
  journal={Anesthesiology},
  year={1992},
  volume={76 5},
  pages={
          743-54
        }
}
Isoflurane/N2O anesthesia has been reported to reduce the cerebral blood flow (CBF) threshold at which electroencephalographic changes occur in humans during carotid occlusion (when compared to halothane/N2O). To further evaluate this observation, normocapnic, normothermic rats were anesthetized with 0.75 MAC isoflurane or halothane in combination with 60% N2O. The electrocorticogram (ECoG) and the cortical DC potential were recorded using glass microelectrodes. Both carotid arteries were… CONTINUE READING
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