A comparison of allografting with autografting for newly diagnosed myeloma.
@article{Bruno2007ACO, title={A comparison of allografting with autografting for newly diagnosed myeloma.}, author={B. Bruno and M. Rotta and F. Patriarca and N. Mordini and B. Allione and F. Carnevale-Schianca and L. Giaccone and R. Sorasio and P. Omede' and I. Baldi and S. Bringhen and M. Massaia and M. Aglietta and A. Levis and A. Gallamini and R. Fanin and A. Palumbo and R. Storb and G. Ciccone and M. Boccadoro}, journal={The New England journal of medicine}, year={2007}, volume={356 11}, pages={ 1110-20 } }
BACKGROUND
In this trial of the treatment of newly diagnosed multiple myeloma, we compared a protocol that entailed a hematopoietic stem-cell autograft followed by an allograft from an HLA-identical sibling with a protocol of tandem autografts.
METHODS
We enrolled 162 consecutive patients with newly diagnosed myeloma who were 65 years of age or younger and who had at least one sibling. All patients were initially treated with vincristine, doxorubicin, and dexamethasone, followed by melphalan… CONTINUE READING
Supplemental Clinical Trials
Interventional Clinical Trial
The treatment assignment is based on the presence or absence of an HLA-identical sibling
donor (Genetic Randomisation, NOT formal Randomisation). Patients with suitable HLA-identical… Expand
Conditions | Multiple Myeloma |
---|---|
Intervention | Procedure |
Paper Mentions
Interventional Clinical Trial
The goal of this clinical trial is to study the feasibility and efficacy of anti-CD19/BCMA
bispecific chimeric antigen receptors (CARs) T cell therapy for relapsed and refractory… Expand
Conditions | Multiple Myeloma in Relapse, Multiple Myeloma Progression |
---|---|
Intervention | Biological, Drug |
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