A comparison of agonist-specific coupling of cloned human alpha(2)-adrenoceptor subtypes.

@article{Rudling2000ACO,
  title={A comparison of agonist-specific coupling of cloned human alpha(2)-adrenoceptor subtypes.},
  author={Jane E Rudling and Joanna Richardson and Peter D. Evans},
  journal={British journal of pharmacology},
  year={2000},
  volume={131 5},
  pages={933-41}
}
The agonist-specific coupling properties of the three cloned human alpha(2)-adrenoceptor subtypes have been compared, when expressed at similar levels in Chinese hamster ovary (CHO) cell lines, using noradrenaline and (+/-)-meta-octopamine as agonists. Noradrenaline can couple the receptor to both the inhibition and stimulation of forskolin-stimulated cyclic AMP production in all three receptor subtypes, with the relative strength of the coupling to the pathways varying for each of the receptor… CONTINUE READING

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